Products
Povidone

Product Name:Povidone

Chemical Name:Polyvinylpyrrolidone,PVP

INCI Name:PVP,Polyvinylpyrrolidone

Formula: (C6H9NO)n

CAS No.:9003-39-8

Referrence:Current USP/NF/EP/BP

Properties:Povidone is homopolymer of 1-vinyl-2-pyrrolidone (Polyvinylpyrrolidone),freely soluble in water,in ethanol (96%),in methanol,and other organic solvents,veryslightly soluble in acetone.It’s a hygroscopic polymer ,supplied in white or creamy white powder or flakes,ranging from low to high viscosity & low to high molecular weight,which characterized by K Value,with excellent hygroscopisty,film-forming,adhesive,chemical stability and toxicological safeness characters.

Key Technical Parameters:

Product

Povidone K15

Povidone K17

Povidone K25

Povidone K30

Povidone K90

Appearance

White or yellowish-white,hygroscopic powder or flakes

Solubility

Freely soluble in water in ethanol(96%)and in methanol,very slightly soluble in acetone

Appearance of Solution

Clearly and not more intensely coloured than reference solution B6,BY6 or R6

Identification

A. IR spectrum obtained is consistent with that abtained with Povidone CRS.

B.An orange-yellow precipitate is formed

C.A pink colour is produced

D.A red colour is produced

E.The substance dissolves

pH(5% aqueous solution)

3.0~5.0

3.0~5.0

3.0~5.0

3.0~5.0

4.0~7.0

K Value

12.75~17.25

15.30~18.36

22.50~27.00

27.00-32.40

81.00~97.20

Aldehydes

500 ppm max.

500 ppm max.

500 ppm max.

500 ppm max.

500 ppm max.

Peroxides

400 ppm max.

400 ppm max.

400 ppm max.

400 ppm max.

400 ppm max.

Formic Acid

0.5% max.

0.5% max.

0.5% max.

0.5% max.

0.5% max.

Hydrazine

1 ppm max.

1 ppm max.

1 ppm max.

1 ppm max.

1 ppm max.

Impurity A(N-Vinylpyrrolidone)

10 ppm max.

10 ppm max.

10 ppm max.

10 ppm max.

10 ppm max.

Impurity B(2-Pyrrolidone)

3.0% max.

3.0% max.

3.0% max.

3.0% max.

3.0% max.

Heavy Metals(As Pb)

10 ppm max.

10 ppm max.

10 ppm max.

10 ppm max.

10 ppm max.

Water

5.0% max.

5.0% max.

5.0% max.

5.0% max.

5.0% max.

Sulphated Ash

0.1% max.

0.1% max.

0.1% max.

0.1% max.

0.1% max.

Nitrogen Content

11.5~12.8%

11.5~12.8%

11.5~12.8%

11.5~12.8%

11.5~12.8%

Applications:Povidone posses excellent binding,film-forming,dispersing and thickening properties.it’s one of the most important excipient in the worldwide for pharmaceutical industry,whatever for human health care products or animal health care products.Which widely used in the pharmaceutical industry as:1)Binder for tables,capsule.It’s suitable for wet and dry granulation and direct compression in tableting,improving the particle compressibility and can be added to powder blends in dry or dissolved by water,alcohol.2)Sugar coatings and films,3)Solubility Improver for poorly soluble drugs,4)Bioavailability Enhancer for drug’s active ingredients,5)Pore-forming for membrane products.

 

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